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FIGURE 4 3 Therapeutic effects of bioactive metabolites in DKD Natural active substances such as polyphenolic metabolites, peptides, polysaccharides, flavonoids, and so on, originate from nature, and have the advantages of high safety, multi-targeted action, abundant resources, and sustainable utilization, which show a great potential for the treatment of DKD ( We explored the therapeutic effects of polyphenols, peptides, polysaccharides, flavonoids, and other bioactive substances in diabetic nephropathy
Other uncommon but serious risks include pancreatitis and gallbladder disease, with gallstones occurring in a small percentage of users during rapid weight loss
We also describe the development of incretin-based pharmacotherapy, starting with exendin- 4 and ending with the identification of multi-incretin hormone receptor agonists, which appear to be the next major step in the fight against T2DM and obesity
Tettamanti et al
Tuttle KR, Bosch-Traberg H, Cherney DZI, Hadjadj S, Lawson J, Mosenzon O, et al
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