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Monitoring progress and response is key to determining the optimal balance between effectiveness and tolerance

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A landmark 2-year randomized, double-blind, placebo-controlled trial (Nass et al., Annals of Internal Medicine, 2008, N=65 healthy elderly adults aged 60-81) demonstrated that 25 mg/day MK-677 restored GH and IGF-1 secretory profiles to levels characteristic of healthy young adults

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Insulin resistance and blood sugar imbalance occur in the development of type 2 diabetes , and may be associated with a defect in fatty-acid metabolism in muscle and tissue lipid (fat) accumulation