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Hence, we speculate that the increase in glucose utilization observed by Peyot et al

Whether a reduced incretin effect (reduced beta cell sensitivity to GIP and/or GLP-1) may play a role in the pathophysiology of NAFLD warrants further investigations

This endothelial dysfunction decreases the potent vasodilator nitric oxide (NO) in endothelial and vascular muscle smooth cells, increases the levels of vasoconstrictors such as endothelin-1 [13], and creates a hypercoagulable state by activating platelet aggregation and inhibiting fibrinolysis [14]

For individuals participating in retatrutide clinical trials, or for those following developments in this area ahead of potential future approval, understanding how to manage GI side effects is important

Patients are instructed to seek immediate medical attention if they experience severe symptoms like difficulty breathing or swelling of the face, lips, or throat