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GLP-1 (glucagon-like peptide-1) agonists, such as Ozempic and Wegovy, have been in the news because of their soaring popularity with celebrities for dramatic weight loss

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These data demonstrated that GLP-1R is the primary target of liraglutide in chondrocytes and macrophages and that the anti-inflammatory effect of liraglutide was mediated by the GLP-1 receptor pathway in both chondrocytes and macrophages

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For GLP-1 compounds, this means providing the receiving site with detailed chemistry, bioreactor run records, and analytical assay SOPs ( [51] )