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Source: Cobalamin: Diagnostic use and therapeutic considerations

For people with an MTHFR mutation, methylcobalamin (as opposed to other forms of B12) is therapeutic

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It is deliberately membrane-permeable, which is what lets it get inside cells and act on an intracellular enzyme

A settling-in reaction is typically a day or two, occasionally up to three

Additionally, low B6 is associated with: Inflammatory conditions like rheumatoid arthritis The onset and progression of Type 2 diabetes, possibly by interfering with the secretion and activity of insulin and other mechanisms