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5-Amino-1MQ binds to the active site of NNMT, effectively blocking the methylation of nicotinamide and preventing its conversion into 1-methylnicotinamide (MNA)

Thus, B12, what gives

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The strongest support comes from clinical evidence focused on treating vitamin B12 deficiency, not from general wellness claims What science supports The NIH Fact Sheet for Health Professionals shows that intramuscular B12 injections are effective at raising blood B12 levels and correcting deficiency

Vitamin B12 also interacts closely with neurotransmitters within the brain and appears beneficial in Autism