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But the two drugs differ in their mechanisms, making tirzepatide potentially more effective for some individuals

Ipamorelin is a selective ghrelin-receptor agonist that amplifies GH pulse amplitude

Pancreatic glucagon is a 29amino acid peptide that regulates glucose homeostasis via gluconeogenesis, glycogenolysis, and lipolysis and is counter regulatory to insulin

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Study cohort entry was defined by the date of the add-on prescription in the combination group and the prescription date of the comparator drug in a given interval

doi: 10.1016/j.phrs.2021.105840 258 TomovaAHusarovaVLakatosovaSBakosJVlkovaBBabinskaKet al