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Ethics declarations Competing interests RS and JPR received research funding for this study from Researched Nutritionals, LLC
Probes mapping to sex chromosomes (X and Y) were excluded (default
This mechanistic complexity explains the consistent failure of nonspecific antioxidant strategies in clinical trials and supports the development of targeted interventions: mitochondria-targeted antioxidants that accumulate selectively in the matrix
In particular, BRCA1/2 mutations and homologous recombination repair deficiency (HRD) have been shown to significantly influence the chemotherapy response
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