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Monolunabant is still a work-in-progress, but aims to take advantage of the appetite-suppressing effects of CB1 without the dangerous side effects
The anatomical distribution of GLP-1R throughout the reproductive system and several preclinical evidence support that GLP-1 can modulate the HPG axis activity at different levels, thus connecting reproductive functions, metabolic system, nutrition, and energy homeostasis mechanisms
People with higher baseline body fat percentages often have greater insulin resistance, altered incretin signaling, and blunted hormonal responses
This side effect typically decreases over time as the body gets used to the medication
Most side effects are stomach-related, and serious risks are rare compared to the health dangers of obesity
In real-world settings, about 65% of people who discontinued a GLP-1 medication (semaglutide or liraglutide in this case) gained weight after stopping treatment
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