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In rats, the reported average was about 3.8 hours after IV dosing and 6.9 hours after oral dosing
Elsevier health sciences
10.1073/pnas.0602266103 Proc
Research has characterised MT-IIs anorectic effects as MC4R-mediated through hypothalamic PVN and arcuate nucleus mechanisms , documenting food intake suppression kinetics, NPY/AgRP pathway suppression, and melanocortin pathway activation markers in hypothalamic tissue following MT-II treatment
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