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Glutathionylation regulates IkappaB

monitoring is reasonable in chronic use

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The polymer backbone covalently integrates an L-buthionine sulfoximine prodrug to inhibit glutathione biosynthesis, and the nanoparticle matrix encapsulates an elesclomol-copper complex to promote intratumoral copper accumulation

This study identified that GHK-Cu at 1 M concentration could modulate the expression of over 4,000 genes, providing mechanistic insight into its broad biological activity profile