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Both the GLP-1 and GIP receptors are expressed on neurons in the arcuate nucleus and other parts of the hypothalamus, and their activation reduce food intake and body weight ( These findings have promoted an interest to discover the CV benefits of this pharmacological class extending beyond its glycemic effect

Clinical research has shown that after discontinuing tirzepatide, people often experience increased hunger and may gradually return to previous eating patterns, which can lead to weight regain

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