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Neither medication is clearly better or worse for fatigue in all cases

discuss with a prescriber) Severe gastroparesis or active uncontrolled GI disease Pregnancy, planning pregnancy within two months, or breastfeeding Type 1 diabetes (not approved

Retatrutide vs tirzepatide is not a simple winner-takes-all question

The supported moves are smaller meals, fiber, hydration, and clinician-guided dose adjustments (Wharton and colleagues, review, 2021)

Rare neuro-ophthalmic events such as ophthalmic migraine warrant monitoring despite low incidence 64

Many researchers dose before bed and upon waking to align with natural GH secretion patterns