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Discussion Individual patient-level data combined with SUSTAIN 6 (once weekly injectable semaglutide versus placebo) and PIONEER 6 (oral semaglutide versus placebo) were collected to assess MACE and HF in patients with and without established CV disease and/or chronic kidney disease, prior MI or stroke, and prior HF
Clinical trials found substantial weight loss and improved cardiovascular outcomes associated with taking these medications
However, patients may experience: Mild bruising at injection site Temporary redness or peeling (peels or lasers) Minor fatigue after IV infusions These effects are temporary and usually subside within hours or days
The JPML found that NAION cases share common factual questions involving: Drug development and clinical testing Marketing and promotional practices Labeling and warning decisions Regulatory history and FDA interactions Scientific evidence linking GLP-1 drugs to optic nerve injury Because the medical mechanisms, risk profiles, and damages associated with permanent vision loss differ significantly from those of gastrointestinal claims, the court concluded that combining them would be inefficient and potentially unfair to plaintiffs
101 (s1), S357S370
