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Consequently, necroptosis creates a pro-inflammatory environment that compromises tissue integrity (134)
Firstly, authors confirmed that cold storage led to a comprehensive reduction in gene expression of inflammatory and metabolic signalling such as oxidative phosphorylation
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doi: 10.1016/j.exger.2008.02.007 122 ReardonTFAllenDG
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The first step is catalyzed by glutamate-cysteine ligase (GCL), which is composed of catalytic and modifier subunits (GCLC and GCLM)
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