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Guloyan et al., 2020
Clinical trials of tirzepatide show heartburn and reflux reported in 812% of participants, most commonly in weeks 14 as the body adapts to slower gastric emptying
It has two mechanisms of action - both a GIP agonist and the GLP-1 agonist to work multiple pathways to aid in the potential to lose weight
Maintaining a balanced nutrition plan, replete with all macronutrients, will prevent this. Besides the potential for oral odor, Khan says people taking GLP-1 medications may experience: Acidic tastes in their mouth Enamel erosion Sensitive teeth Gingivitis Tooth decay Khan notes that people with gastro-esophageal (GERD) may experience frequent heartburn as well as a bitter and acidic taste in their GERD
