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Allison, who has worked for a decade on correcting statistical errors in the nutrition literature, asked some of his mentees to see if they could make sense of the papers analysis, he said

It first drew research interest for its ability to heal stomach ulcers and inflammatory bowel conditions, then expanded to tendon, ligament, muscle, and even bone healing across dozens of preclinical studies (Sikiric et al., PubMed)

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However, in the agent-level analysis, tirzepatide only demonstrated significant reductions in MACE when compared to placebo, while other endpoints showed favorable but non-significant trends