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The type of control and study location were identified as sources of high heterogeneity following subgroup analysis
The primary objective of FLOW was to demonstrate that Ozempic delays the progression of renal impairment and lowers the risk of renal and cardiovascular mortality compared to placebo, both added to standard-of-care, in subjects with type 2 diabetes and chronic kidney disease
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Key exclusion criteria included a history of cardiovascular disease, uncontrolled hypertension, and previous bariatric surgery
Both substances work through different mechanisms, which means they do not compete for the same receptors or metabolic pathways
Peptides for menopause-related weight work faster when triple-agonist mechanisms accelerate fat mobilization beyond what single-agonist therapies achieve
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