Chloroquine treatment has been shown to cause aspartate depletion, which limits nucleotide synthesis [95, 96]
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Cons: It can cause weight gain in the form of water weight (although this can be a pro for some athletes, and that water retention is actually not a bad thing it is mostly intracellular)
Without documentation, gradual changes often go unnoticed, and the lack of perceived progress can lead to premature discontinuation