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Bert said that multiple studies show that there is potential for an increase of NAION

Isoflavones are phytoestrogenic, which means they can bind to estrogen receptors and mimic the effects of the hormone estrogen in the body, which provides protection against cardiovascular disease, especially in postmenopausal women ( 3.1.4 Flavanones Naringenin and hesperidin, flavanones predominantly found in citrus fruits, have a more saturated C-ring structure than flavones or flavonols

[3] [4] Based on Phase 2 clinical trial data published in the New England Journal of Medicine in 2023 covering both obesity and type 2 diabetes populations retatrutide was administered as a once-weekly subcutaneous injection within those trial protocols

Compared to placebo, which showed only a 4.5% reduction, the higher doses delivered statistically significant improvements

Barreto, A

All statistical analyses were imported and performed in GraphPad Prism