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Options for managing tolerance include a brief dose reduction for 4 to 8 weeks ("drug holiday" at a lower dose, not complete cessation), lifestyle optimization to maximize the medication effect, evaluation for other contributing factors (thyroid function, cortisol, sleep quality, medication interactions), and consideration of adding a complementary compound to address specific aspects of the plateau

The water is then slowly injected into the vial, allowing the lyophilized powder to dissolve gradually

Glia 70, 19381949

Now of course it's correlative, now they feel better they're doing it

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