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Additionally, improved glycemic control with GLP-1 RAs in T2DM patients may reduce glycosuria, a process known as glycemic buffering, which reduces caloric loss through urine and offsets part of the energy deficit induced by treatment [43,44,45]
Or, more specifically, an insatiable need for it
At the same time, the drug development horizon is full of promising directions: oral formulations, multi-agonists, longer-acting molecules, and the emergence of biomarkers to personalize therapy
Pharmacol Res 1998;37(2):115-122
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