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New England Journal of Medicine (2025) 2

M., & Legator, M

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Several cardiovascular outcome trials (CVOTs) have also reported that GLP-1 RAs may be associated with mitigating kidney-related outcomes, including albuminuria, decline in eGFR and the risk of end-stage kidney disease, independent of their effects on glycemic control 14,15,17,26,27

It is increasingly recognized as a regulatory mechanism and potential biomarker in oxidative stress-associated conditions such as cardiovascular disease, cancer, and neurodegenerative disorders