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Nieber K, Baumgarten CR, Rathsack R, Furkert J, Oehme P, Kunkel G, Substance P
Now, two new late-phase clinical trials, sponsored by Eli Lilly and Company, suggest that transitioning from high dose injectable weight loss medications to either a daily pill or a lower maintenance dose can help people living with obesity to keep off most of the weight they have already lost The results of the ATTAIN-MAINTAIN and SURMOUNT-MAINTAIN trials were presented at the European Congress on Obesity and published in Previous research suggests that 1 year after stopping weight loss medication, people may regain, on average, 60% of their lost weight
The SEMALEAN study (2025) found a 15% reduction in visceral fat and an average weight loss of 12 kg over six months
This article reviews the emerging trend of microdosing GLP-1 drugs, examining potential benefits, risks, and the current lack of scientific evidence supporting this approach
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