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Berberine can interact with a number of medications, including antidiabetic agents, blood thinners, and drugs processed by cytochrome P450 enzymes

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At the CNS level, long-term use of SSRIs could increase extracellular levels of 5-HT by inhibiting SERT, preventing it from degrading to 5-HIAA and thus making more 5-HT available to bind to neuronal 5-HT1A receptors and improve fatigue [395]

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So I mean, its just its going to explode even more than what it has today

placebo) [61]