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Erastin is a small molecule that inhibits the cellular import of cystine, a key component of GSH, thus lowering the levels of intracellular GSH 23 (Fig 4A)
Notably, in MMTV-ErbB2 transgenic mice, the CSC subpopulation was most affected by CR, as shown by a reduction of luminal cells (CD24 high /CD49f low ), putative mammary reconstituting unit subpopulations (CD24 high /CD49f high ) and luminal progenitor cells (CD61 high /CD49f high )
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The gut-brain axis response, including improvements in fatigue and cognitive clarity that many patients attribute to gut inflammation, often follows several weeks later
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