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Mutant IDH1 leads to the accumulation of the metabolite 2-hydroxyglutarate (2-HG), which stabilizes HIF-1, further promoting immune suppression in the TME
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Despite normalization of plasma homocysteine concentration, administration of folic acid, vitamin B 6 , and vitamin B 12 for 6 months was insufficient to restore normal vascular function in monkeys maintained for 17 months on an atherosclerotic diet that produced both hypercholesterolemia and hyperhomocysteinemia (Lentz et al, 1997)
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