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Human peptide trials have involved small sample sizes and, sometimes, loose protocols with no blinding or placebo controls
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Moreover, One mechanism through which RNS contributes to IBD pathology is the formation of Peroxynitrite(ONOO-), a highly reactive oxidant formed by the reaction of NO with O2 (148)
Key limitations hindering clinical translation include: (1) Formula standardization gaps : Current research predominantly focuses on empirical or self-formulated TCM prescriptions, with insufficient validation of classical prescriptions through randomized controlled trials
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