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Patients with Wilson's disease should not use any copper-containing therapy

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Pituitary negative feedback via somatostatin and IGF-1 remains intact, preserving the physiological safety margin of GHRH-based approaches

In shock probe paradigms, BPC-157-treated rats showed reduced burying behavior without increased shock reception (a different profile from diazepam)

Surgery success rates are generally good for pain relief (70 to 90% improvement in leg pain symptoms), but come with risks: infection, nerve damage, disc reherniation (5 to 15% recurrence rate after microdiscectomy), and adjacent segment disease with fusion (20 to 30% develop problems within 10 years)

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