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Eisenberg D, Shikora SA, Aarts E, et al

Others may not connect the cramps to semaglutide, especially if they have experienced cramps in the past

For example, the SELECT trial showed a 20% improvement in major cardiovascular events (i.e., heart attacks, strokes, and deaths from those cases) in adults on weekly semaglutide who were overweight or obese (without diabetes) and with preexisting cardiovascular disease, as well as an improvement in all-cause mortality of 19%

The benefits exceed what would be expected from glucose control alone, suggesting direct protective effects beyond metabolic improvement

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