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Many individuals with type 2 diabetes or obesity take multiple medications that independently cause xerostomia, including antihypertensives (particularly diuretics), antidepressants, antihistamines, and other medications with anticholinergic properties

Extended fasting increases the risk of low blood sugar and digestive side effects

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Citation98,Citation99 Then, the hydrophobic C-terminal of AMP may insert into the hydrophobic region of the cell membrane, which may change the conformation of the cell membrane and reduce the activity of P-gp by inhibiting the efflux of chemotherapy drugs, increasing the intracellular drug concentration, and reversing drug resistance of MDR tumor cells