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Another potential limitation of a TTE approach is the dichotomization of the MDS-UPDRS, a continuous scale, which can lead to a potential disadvantage of reduced accuracy and pose the question of the variability around the threshold and its acceptability

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medication adherence is the most important factor in achieving sustainable results (Polonsky et al., Diabetes Care , 2020)

If additional glycemic control is needed, the dose can be increased to 1 mg once weekly after at least four weeks, and further to a maximum of 2 mg once weekly if necessary

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