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Inoue, H

Tirzepatide activates both the GLP-1 and GIP receptors, while Ozempic (semaglutide) targets only the GLP-1 receptor

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Long-term use of semaglutide in the presence of unmanaged acid reflux could potentially lead to complications associated with chronic GERD, such as esophagitis or Barretts esophagus

The current evidence suggests that tirzepatide, like other GLP-1 medications, works best as a long-term or indefinite treatment