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Repeat labs (A1c, lipids, kidney, liver) to track metabolic improvements, not just weight

the possibility exists that dual incretin receptor agonists work mainly by potent activation of the GLP-1R

15 There are 31 secondary endpoints, including, achievement of 10, 15%, and 20% body weight reduction, and absolute changes from baseline to Week 76 in: 15 Body weight Waist circumference Blood pressure Body Mass Index (BMI) Glycosylated hemoglobin A1c (HbA1c) Total cholesterol Liver fat content Body composition sub study endpoints included absolute and relative change in: Total fat volume Lean body volume Visceral fat volume Subcutaneous fat volume About the SYNCHRONIZE-MASLD trial (NCT06309992) This is a Phase III, double-blind, placebo-controlled 48-week efficacy and safety trial of survodutide among 218 adults living with obesity and overweight and with MASLD with evidence of inflammation and or fibrosis versus placebo

Amidst this backdrop, GLP-1 medications have emerged as groundbreaking tools for many seeking to shed excess weight

GLP-1 users who stopped taking the drugs for a year had a 14 percent increased risk of cardiovascular events