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cAMP activates PKA and Epac-2 signal transduction pathways, PKA and Epac-2 lead to the closure of ATP-sensitive potassium channels, which in turn causes depolarization of the cell membrane and opening of voltage-dependent calcium channels, resulting in uptake of calcium and stimulation of the exocytosis of insulin granules and blood glucose control of T2DM patients

The clinical observations are encouraging

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PCOS causes symptoms such as irregular menstrual cycles, insulin resistance, hirsutism (excess hair growth, especially on the face think those pesky chin hairs!), acne, male pattern baldness, and anovulation