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Several patient characteristics may increase the risk of gastrointestinal complications, particularly ischemic colitis, though specific risk factors for semaglutide-associated colitis have not been definitively established

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doi:10.1016/S2213-8587(25)00092-0

In large-scale studies, semaglutide (the active ingredient in Ozempic and Wegovy) led to an average placebo-corrected weight loss of about 12.4% at the 2.4 mg dose

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