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Abstract Parkinsons disease (PD), the second most common neurodegenerative disorder worldwide, features gradual loss of dopaminergic neurons in the substantia nigra pars compacta (SNpc) along with pathological -synuclein (-syn) aggregation

Delayed treatment may fail to mitigate the oxidative cascade, while early intervention could interfere with beneficial immune responses that rely on ROS for pathogen clearance (Forman and Zhang, 2021)

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