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The total human evidence base, as of this writing, consists of the following: 1) a Phase I safety trial of 42 healthy volunteers that was registered in 2015, canceled in 2016, and never published, 2) a retrospective case series of 12 patients with knee pain, no control group, and no validated outcome measure, and 3) a 2025 pilot safety study involving two healthy adults who received intravenous infusions at a single private clinic in Florida

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I ran an 8-week cycle and took a month off afterward

10.1007/s10787-006-1531-7 72 SikiricP.SeiwerthS.BrcicL.SeverM.KlicekR.RadicB.et al (2010)

Altering this pathway through NNMT inhibition has been shown in preclinical settings to increase caloric expenditure while reducing storage