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[38] In 2022 alone, the company paid $34 million to physicians for consulting, promotional speaking, and other non-research related work

But as their use has grown, so have questions about their impact on digestion

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The two pathways don't overlap, which means research designs can probe both vascular and cytoskeletal mechanisms simultaneously without confounding mechanism-specific effects

Lastly, the sample size, while adequately powered for a composite endpoint design [57], can be improved in subsequent studies based on the data from the current one