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Finally, although investigators often excluded individuals with any other systemic diseases (diabetes mellitus, abnormal lipid profile, cardiovascular, kidney and/or liver diseases) [1824, 2832, 3640, 61], the wash-out period (treatment free period before blood collection) was very variable (2 weeks - 6 months) [20, 21, 23, 27, 2932, 3640, 44, 59, 61]

Data availability The nuclear magnetic resonance and mass spectrometry data are provided in the Supplementary Information

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one was a control, and the other was labeled as the DSIP group