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No participants withdrew from any trial due to tolerability issues, indicating that even when side effects occurred, they were sufficiently manageable that participants chose to continue treatment

One major advantage of intramuscular injection is that its increasingly effective at raising blood levels of B12

doi: 10.2174/157015913666160502153022

A Brief History: From Abstinence-Only to Evidence-Based Pharmacotherapy The treatment of SUD has historically leaned heavily on abstinence and psychotherapy

This dual mechanism distinguishes it from precursor supplementation in research terms