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The durability of the glucagon-mediated metabolic changes after drug washout is an open research question that Phase 3 extension studies are expected to address

& Blumberg, P

TRAP-1 supports tumor growth by promoting glycolysis, inhibiting succinate dehydrogenase, and activating cytochrome-c oxidase, 234,235,236 although reduced TRAP-1 expression at later stages has been linked to enhanced motility and invasion, suggesting context-dependent roles

[1] TML is then hydroxylated into hydroxytrimethyllysine (HTML) by trimethyllysine dioxygenase (TMLD), requiring the presence of ascorbic acid and iron

Biol (Basel) (2020) 9(6):126

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