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Semaglutide and tirzepatide studies show about 60% of lost weight returning within a year, with most regain in the first months and about one-third to 40% of the loss still held at one year. Retatrutide may produce greater regain pressure because its glucagon support for resting metabolism fades while appetite returns

Therefore, we performed this meta-analysis to clarify the association of GLP-1 receptor agonists with thyroid disease in clinical studies and preparation for future studies in humans

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Oxidative stress: Signaling pathways, biological functions, and disease