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Phentermine is a Schedule IV controlled substance with some potential for dependence

Human outcome data is limited

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Mix Vitamin B12 powder from a supplement with coconut oil and a few drops of tea tree oil for an external remedy

Appetite Effects The question about appetite is interesting because the proposed mechanism could reasonably go either direction: Reduced lipogenesis and improved metabolic flexibility could produce secondary effects on appetite regulation NAD+ restoration has complex effects on hypothalamic appetite signaling Preclinical data do not consistently describe dramatic appetite changes In human use were it to become clinically available patient-reported appetite effects would be a relevant monitoring parameter, but the data do not currently support a strong a priori expectation

However, there are a few rare cases where this treatment is not recommended