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It has been reported that acetaminophen injection led to a significant release of intracellular iron and subsequent ROS accumulation by activating ferritinophagy on the one hand and inhibiting the endogenous nuclear factor E2-related factor 2 (Nrf2)/heme oxygenase-1 (HO-1) antioxidant pathway on the other hand, which contributes to clear intracellular ROS

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Common reactions include nausea, flushing, appetite suppression, and fatigue