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Mutation of allosteric hot spot residues alter the allosteric communications In order to examine how the triangular allosteric network responds to the mutations of key residues, we have prepared three GDH mutants in silico using Chimera rotamers tools 29 GDH Ser441Leu , GDH Arg217Cys , and GDH Gly376Asp

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6 Conclusion Gastric cancer is the third leading cause of cancer-related death worldwide

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It has been used in traditional medicine for centuries and is now widely studied for its effects on blood sugar, cholesterol, gut health, and metabolic function

L., Aslett, M., Guiliano, D