Mehta P, McAuley DF, Brown M, Sanchez E, Tattersall RS, Manson JJ
Almost certainly yes, with requirements
Abbreviations ADA: American Diabetes Association AE: Adverse event ASCVD: Atherosclerotic cardiovascular disease CI: Confidence interval CKD: Chronic kidney disease CVOT: Cardiovascular outcomes trial EASD: European Association for the Study of Diabetes eGFR: Estimated glomerular filtration rate GLP-1RA: Glucagon-like peptide-1 receptor agonist HbA1c: Hemoglobin A1c HF: Heart failure HHF: Hospitalization for heart failure HR: Hazard ratio MACE: Major adverse cardiovascular events OR: Odds ratio RCT: Randomized controlled trial RR: Relative risk SBP: Systolic blood pressure SGLT2i: Sodium-glucose cotransporter-2 inhibitor T2DM: Type 2 diabetes mellitus References Daz-Trastoy O, Villar-Taibo R, Sifontes-Dubn M, Mozo-Pealver H, Bernabeu-Morn I, Cabezas-Agrcola JM, et al
Several events seen in the brain of neurodegenerative diseases could give rise to an abnormal production of reactive oxygen spices (ROS)
Essentially zero
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