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PMID 12565892
Nevertheless, chondrocyte senescence refers to the irreversible growth arrest of cartilage cells, characterized by altered gene expression, impaired matrix production, and secretion of pro-inflammatory and degradative factors collectively known as the senescence-associated secretory phenotype (SASP) (Loeser, 2009)
HAVCR2 is a Th1-specific cell surface protein that regulates macrophage activation, and inhibits Th1-mediated auto- and alloimmune responses, and promotes immunological tolerance
Our model simulations are reflective of the hepatic GSH environment, agreeing with the supra-pharmacological concentrations of doxorubicin required to illicit comparable GSH depletion in the liver 39
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