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Single-pot glycoprotein biosynthesis using a cell-free transcription-translation system enriched with glycosylation machinery
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Data availability All data and materials not already presented in this work may be made available upon request
The trial enrolled 445 adults with obesity and moderate-to-severe knee osteoarthritis pain (without diabetes), randomized 1:1:1 to 9mg, 12mg, or placebo over 68 weeks
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The FDA requires warnings on all obesity medications regarding suicidal ideation, but this reflects regulatory caution rather than demonstrated causation for Retatrutide specifically
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