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The standard schedule begins at 0.3 mg weekly for four weeks, then escalates to 0.6 mg for four weeks, followed by 1.2 mg for four weeks, then 1.8 mg for four weeks, ultimately reaching the maintenance dose of 2.4 mg weekly

Unlike traditional CAR T therapies that require cell harvesting, engineering and reinfusion, Interius off-the-shelf yet personalized approach is designed to be delivered via a single intravenous infusion, eliminating the need for preconditioning chemotherapy and complex cell processing

Figure 3g and Supplementary Fig

It was originally studied in the context of gastrointestinal healing, where the parent protein appears to play a role in protecting the gut lining

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Inspection of the BMI % phenotype revealed a heavy tailed distribution, so we further quality controlled the BMI % phenotype to remove outlier participants with BMI changes above 20% or below 45% (Extended Data Fig